Metabolic challenges caused by increasing obesity and aging population are threatening bone health. This session will explore the interplay between bone health and metabolic diseases, including diabetes, hyperlipidemia, and obesity. By deepening our understanding of how they interact and affect overall health, we hope to improve comprehensive approach to patients with these widespread and often coexisting diseases.

This session addresses key challenges in osteoporosis management, featuring Prof. Yumie Rhee (Yonsei University) presenting recent updates in patient-tailored treatment strategies, Prof. Yong Jun Choi (Ajou University) examining special considerations for treatment failure cases after denosumab use, and Prof. So Young Park (Kyunghee University) reviewing current evidence on the impact of low-dose inhaled glucocorticoids on bone health. Each topic will provide practical solutions for challenges encountered in clinical settings in osteoporosis management.

This lecture will cover new approaches to the development of osteoporosis therapeutics. Professor Matthew T. Drake will present the first clinical results with a simultaneous inhibitor of sclerostin and DKK1, Professor Won-Bong Lim will present the results of a novel osteoporosis therapeutic targeting a novel RANKL receptor, and Professor Chuan-Ju Liu will present the development of a novel osteoporosis therapeutic targeting tau protein and low-affinity glucocorticoid receptor. This lecture will provide useful insights for researchers and clinicians who want to understand the current trends and clinical applicability of osteoporosis therapeutics.